Never laugh at somebody else's problems - they might seem insignificant to you but they might mean a lot to them.
We sometimes disparagingly call noise, music that's insignificant and devoid of any charm.
I'm so unimportant and insignificant.
Relative to overall sales, that of software is insignificant.
We're quite insignificant, but awesome nevertheless.
Every time a man is begotten and born, the clock of human life is wound up anew to repeat once more its same old tune that has already been played innumerable times, movement by movement and measure by measure, with insignificant variations.